Buprenorphine-D4.HCl is an internal standard used for the quantification of buprenorphine.HCl. Buprenorphine.HCl is a semisynthetic opioid used to manage opioid dependence and to treat chronic pain. It is sold under brand names such as Subutex, among others. Buprenorphine-D4.HCl is available as reference material (bulk powder and/or solution) and as calibrated, Ready-to-Use, certified reference material (CRM). This product is designed for use in qualitative and quantitative protocols and can be used for forensic, toxicology, research, and other chemical/biochemical analytical applications.